Endocrine Abstracts

Objective: Androgen may be detrimental in the development of cardiovascular disease in women. We investigated possible associations between the (TAAAA)n polymorphism of sex hormone binding globulin (SHBG) gene promoter, which influences transcriptional efficiency of the SHBG gene and thus the tissue androgen availability and early markers of atherosclerosis in apparently healthy women.Design and methods: In this prospective clinical study, 153 con...

Background: Subclinical Cushing’s syndrome (SCS) due to incidentally discovered adrenal adenomas (AI) has been associated with increased prevalence of hypertension, obesity, and impaired glucose tolerance which are established risk factors for cardiovascular morbidity. Although functional and morphological (structural) changes of endothelium have been correlated with cardiovascular morbidity this has not been looked into detail in patients with adrenal incidentalomas....

Background: The renin-angiotensin system is important for blood pressure control. Screening and diagnostic tests used so far to diagnose patients with aldosterone related hypertension does not take into consideration the stimulating ACTH effect on aldosterone secretion.Objective: To assess the role of aldosterone in essential hypertension using a modified suppression test, performed under suppressed ACTH levels.Subjects and methods...

Hypothalamic hormonal deficiency and anterior pituitary hormonal deficiency is a rare occurrence in patients presenting with HIV infection. We describe a patient with HIV infection who presented with secondary amenorrhea as the initial manifestation.Case report: A 34-year-old woman with previously regular menses presented with secondary amenorrhea by 9 months. The patient had mild gait instability for 7 months; anorexia and weight loss (10 kg) for the la...

Background CPHD is characterized by GH and at least one other pituitary hormone deficiency. Mutations in genes expressed in the developing head, hypothalamus, and/or pituitary cause CPHD. To date around 30 genes have been identified to be related to CPHD, however 85% of the cases remain with unknown molecular aetiology.Patient and methodsA newborn boy (46, XY) delivered by CS due to IUGR with a birthweight of...

IntroductionPrimary hyperparathyroidism (PHPT) is characterized by excessive secretion of parathyroid hormone (PTH) from one or more parathyroid glands. PTH has a central role in the regulation of calcium and phosphate and the classic disorder causes primarily hypercalcemia associated with renal and bone manifestations. Non-classical symptoms are also present including cardiovascular, gastrointestinal, psychiatric, neuro-cognitive disorders. Regarding ca...

IntroductionThe differential diagnosis between benign and malignant parathyroid neoplasms may be challenging and should always be based on clinical and histological criteria. We are presenting a case series of three patients with clinical, biochemical and imaging findings supporting the presence of a malignant neoplasm but histological findings confirming the diagnosis of a parathyroid adenoma.Case 1A 24-year...